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The Impact of Merremia mammosa (Lour) on Wound Mending Procedure and Glucose Level of Hyperglycemic Male Rats

Diabetes mellitus (DM) is an endocrine issue which is portrayed by high blood glucose levels. The predominance of DM in Indonesia increments continouosly. The inconvenience of diabetes normally is the diabetic wound, which is described by drag out recuperated wounds due to the lengthened incendiary stage. Merremia mammosa is one of Indonesian plant, which is customarily utilized for diabetes Mellitus and wound treatment. Flavonoids which is contained in Bidara Upas has calming and against diabetic impacts that will influence the injury mending procedure and lessening glucose levels. The goal of this review was to affirm the injury recuperating and against diabetic movement of Bidara Upas roots separate on hyperglycemic rats. 

The hyperglycemic rats were injured utilizing the change of Morton strategy. A hyperglycemic condition in rats was made by alloxan acceptance. The examples were isolated into 4 bunches (n=5). Gather P1 was negative control (NaCl). Amass P2, P3, and P4 were concentrate treated gatherings. The concentrates were given topically at dosages 100mg/day, 200mg/day, and 400mg/day for 21 days, individually. 

Wound territory and mending rate were measured regular for 21 days. The outcomes demonstrated that Bidara Upas roots remove significantly affected injury ending in hyperglycemic rats with p<0,05 (p=0,029 on day-1, p=0,001 on day-3, p=0,000 on day-5, p=0,002 on day 7, p=0,004 on day-14 and p=0,000 on day-21), yet there is no noteworthy impact on glucose levels with p>0,05 (p=0,051 on day-1, p=0,336 on day-3, p=0,447 on day-5, p=0,375 on day-7, p=0,052 on day-14 and p=0,448 on day-21).

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